Research

About the Study:

This study, run by the Bladder Infection and Immunity Group at University College London (UCL) in partnership with the Whittington Hospital, is investigating whether vaginal therapies – vaginal oestrogen and boric acid – can help reduce the frequency and severity of chronic UTIs in post-menopausal women, alongside antibiotic and antiseptic therapies.

We know that the vaginal microbiome (the community of bacteria living in the vagina) is closely linked to bladder and urethral health. Both vaginal oestrogen and boric acid have been shown to improve vaginal microbiome health, and we want to find out whether this translates into fewer and less severe UTIs.

Who can take part?

We are looking for:

• Post-menopausal women aged 40 and above who experience recurrent or chronic UTIs 
• We are especially in need of those using Boric Acid suppositories, or those using no vaginal medication at all

What does taking part involve?

The study runs over six months and involves up to four appointments, three months apart. However, if you are unable to commit to the full study, a one-off appointment is still very welcome. At each visit, a urine sample and vaginal swabs will be collected, and you will be asked to complete a few symptom questionnaires. You will have the opportunity to discuss your treatment with your doctor throughout as this will be completed within your usual appointment. You will also receive personalised results of the vaginal swab analysed under the microscope.

Is it safe?

Both vaginal oestrogen and boric acid are well-established and generally very safe therapies. Any side effects will be carefully monitored throughout the study, and you can speak to the team at any time if you have concerns. Participation is entirely voluntary and you can withdraw at any time without it affecting your care.

Contact us here to find out more!